BDBM13284 N-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}phenyl)acetamide::N-[4-[amino(imino)methyl]-2-({(3S)-3-[[(7-methoxy-2-naphthyl)sulfonyl](methyl)amino]-2-oxopyrrolidin-1-yl}methyl)phenyl]acetamide::Sulfonamidopyrrolidinone 14
SMILES: COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2cc(ccc2NC(C)=O)C(N)=N)C1=O
InChI Key: InChIKey=XGLNNPQGQSORDQ-DEOSSOPVSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM13284 (N-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 919 | -8.15 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Rhone-Poulenc Rorer | Assay Description The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... | J Med Chem 42: 3572-87 (1999) Article DOI: 10.1021/jm990041+ BindingDB Entry DOI: 10.7270/Q2KW5D9R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin (Bos taurus (bovine)) | BDBM13284 (N-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthale...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.90E+3 | >-7.47 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Rhone-Poulenc Rorer | Assay Description The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... | J Med Chem 42: 3572-87 (1999) Article DOI: 10.1021/jm990041+ BindingDB Entry DOI: 10.7270/Q2KW5D9R | |||||||||||
More data for this Ligand-Target Pair |