BDBM13355 6-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3-benzothiazole-2,6-dicarboxamide::CHEMBL67758::benzothiazole analog 11

SMILES: Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3)sc2c1

InChI Key: InChIKey=TWKVMAOWCHQYRF-UHFFFAOYSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 13355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13355 (6-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...) Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3)sc2c1 Show InChI InChI=1S/C19H16ClN3O2S/c1-10-3-2-4-13(20)16(10)22-18(25)12-7-8-14-15(9-12)26-19(21-14)23-17(24)11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,22,25)(H,21,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of phosphorylation ofan exogenous substrate by human p56 Lck tyrosine kinase expressed as a Histagged protein in insect cells usi...				Bioorg Med Chem Lett 13: 2145-9 (2003) BindingDB Entry DOI: 10.7270/Q2F76BZ1
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13355 (6-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...) Show SMILES Cc1cccc(Cl)c1NC(=O)c1ccc2nc(NC(=O)C3CC3)sc2c1 Show InChI InChI=1S/C19H16ClN3O2S/c1-10-3-2-4-13(20)16(10)22-18(25)12-7-8-14-15(9-12)26-19(21-14)23-17(24)11-5-6-11/h2-4,7-9,11H,5-6H2,1H3,(H,22,25)(H,21,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair