BDBM133563 US8846719, 255

SMILES: Cc1onc(c1COc1ccc(cn1)C(=O)Nc1cnn(C)c1)-c1ccc(Cl)cc1

InChI Key: InChIKey=HDNWJKMMTZAYSO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 133563   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) (Homo sapiens (Human))	BDBM133563 (US8846719, 255) Show SMILES Cc1onc(c1COc1ccc(cn1)C(=O)Nc1cnn(C)c1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C21H18ClN5O3/c1-13-18(20(26-30-13)14-3-6-16(22)7-4-14)12-29-19-8-5-15(9-23-19)21(28)25-17-10-24-27(2)11-17/h3-11H,12H2,1-2H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.800	-11.5	n/a	n/a	n/a	n/a	n/a	7.5	4
Roche Palo Alto LLC US Patent					Assay Description Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...				US Patent US8846719 (2014) BindingDB Entry DOI: 10.7270/Q2V986RV
					More data for this Ligand-Target Pair