BDBM133710 US8846699, 26

SMILES: Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)C=C)c(NC(=O)C=C)cc12

InChI Key: InChIKey=YOHNLHXVSFTRLR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 133710   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM133710 (US8846699, 26) Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)C=C)c(NC(=O)C=C)cc12 Show InChI InChI=1S/C22H19BrFN5O3/c1-3-20(30)25-7-8-32-19-11-17-14(10-18(19)28-21(31)4-2)22(27-12-26-17)29-16-6-5-13(23)9-15(16)24/h3-6,9-12H,1-2,7-8H2,(H,25,30)(H,28,31)(H,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
Hanmi Pharm. Co., Ltd. US Patent					Assay Description EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...				US Patent US8846699 (2014) BindingDB Entry DOI: 10.7270/Q2KW5DRK
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM133710 (US8846699, 26) Show SMILES Fc1cc(Br)ccc1Nc1ncnc2cc(OCCNC(=O)C=C)c(NC(=O)C=C)cc12 Show InChI InChI=1S/C22H19BrFN5O3/c1-3-20(30)25-7-8-32-19-11-17-14(10-18(19)28-21(31)4-2)22(27-12-26-17)29-16-6-5-13(23)9-15(16)24/h3-6,9-12H,1-2,7-8H2,(H,25,30)(H,28,31)(H,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	7.4	25
Hanmi Pharm. Co., Ltd. US Patent					Assay Description VEGFR2 (KDR, Proquinase) enzyme assay (auto-phosphorylation assay) was carried out by using Tyrosine Kinase Assay Kit Green (Panvera). The entire ass...				US Patent US8846699 (2014) BindingDB Entry DOI: 10.7270/Q2KW5DRK
					More data for this Ligand-Target Pair