BDBM13384 4-{[(R)-(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl}-3-(3-methoxyphenyl)benzonitrile::A313326 Analogue 20
SMILES: COc1cccc(c1)-c1cc(ccc1CO[C@@H](c1cncn1C)c1ccc(cc1)C#N)C#N
InChI Key: InChIKey=QQZYKSKGVSDVOW-HHHXNRCGSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl transferase type I (Bos taurus (bovine)) | BDBM13384 (4-{[(R)-(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Globe Pharmaceutical R and Abbott Laboratories | Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we... | J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyl/geranylgeranyl transferase (Homo sapiens (Human)) | BDBM13384 (4-{[(R)-(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Globe Pharmaceutical R and Abbott Laboratories | Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we... | J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D | |||||||||||
More data for this Ligand-Target Pair |