BDBM134086 US8846689, 88

SMILES: COc1cc(ccc1Nc1ncc(c(Oc2cccc3C(C)N(C)C(=O)c23)n1)C(F)(F)F)C(=O)N[C@H]1CCN(C)C[C@H]1F

InChI Key: InChIKey=DQIFHEDEBGXPBE-ONDDXQNRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM134086 (US8846689, 88) Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc3C(C)N(C)C(=O)c23)n1)C(F)(F)F)C(=O)N[C@H]1CCN(C)C[C@H]1F |r,w:20.22| Show InChI InChI=1S/C29H30F4N6O4/c1-15-17-6-5-7-22(24(17)27(41)39(15)3)43-26-18(29(31,32)33)13-34-28(37-26)36-21-9-8-16(12-23(21)42-4)25(40)35-20-10-11-38(2)14-19(20)30/h5-9,12-13,15,19-20H,10-11,14H2,1-4H3,(H,35,40)(H,34,36,37)/t15?,19-,20+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...				US Patent US8846689 (2014) BindingDB Entry DOI: 10.7270/Q2BC3X7Z
					More data for this Ligand-Target Pair