BDBM134103 US8846689, 105

SMILES: COc1cc(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@H]23)ccc1Nc1ncc(c(Oc2cccc3C(C)N(C)C(=O)c23)n1)C(F)(F)F

InChI Key: InChIKey=XFMKVNOLFQRJQO-QYSXHXMRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134103   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM134103 (US8846689, 105) Show SMILES COc1cc(O[C@@H]2CO[C@@H]3[C@H](O)CO[C@H]23)ccc1Nc1ncc(c(Oc2cccc3C(C)N(C)C(=O)c23)n1)C(F)(F)F |r,w:30.34| Show InChI InChI=1S/C28H27F3N4O7/c1-13-15-5-4-6-19(22(15)26(37)35(13)2)42-25-16(28(29,30)31)10-32-27(34-25)33-17-8-7-14(9-20(17)38-3)41-21-12-40-23-18(36)11-39-24(21)23/h4-10,13,18,21,23-24,36H,11-12H2,1-3H3,(H,32,33,34)/t13?,18-,21-,23-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...				US Patent US8846689 (2014) BindingDB Entry DOI: 10.7270/Q2BC3X7Z
					More data for this Ligand-Target Pair