BDBM134119 US8846689, 121

SMILES: CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(c(Oc3cccc4c3C(=O)N(C)C4(C)C)n2)C(F)(F)F)cc1Cl

InChI Key: InChIKey=IOGNPABAZCILJZ-YKSBVNFPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134119   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM134119 (US8846689, 121) Show SMILES CO[C@H]1CN(C)CC[C@H]1NC(=O)c1cc(OC)c(Nc2ncc(c(Oc3cccc4c3C(=O)N(C)C4(C)C)n2)C(F)(F)F)cc1Cl |r| Show InChI InChI=1S/C31H34ClF3N6O5/c1-30(2)17-8-7-9-22(25(17)28(43)41(30)4)46-27-18(31(33,34)35)14-36-29(39-27)38-21-13-19(32)16(12-23(21)44-5)26(42)37-20-10-11-40(3)15-24(20)45-6/h7-9,12-14,20,24H,10-11,15H2,1-6H3,(H,37,42)(H,36,38,39)/t20-,24+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...				US Patent US8846689 (2014) BindingDB Entry DOI: 10.7270/Q2BC3X7Z
					More data for this Ligand-Target Pair