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SMILES: COc1cc(C(=O)NCCN(C)C)c(F)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F

InChI Key: InChIKey=OVQQDUQZWDFUAO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134123   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM134123
PNG
(US8846689, 125)
Show SMILES COc1cc(C(=O)NCCN(C)C)c(F)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F
Show InChI InChI=1S/C26H26F4N6O4/c1-35(2)9-8-31-22(37)15-10-20(39-4)18(11-17(15)27)33-25-32-12-16(26(28,29)30)23(34-25)40-19-7-5-6-14-13-36(3)24(38)21(14)19/h5-7,10-12H,8-9,13H2,1-4H3,(H,31,37)(H,32,33,34)
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Similars
US Patent
n/an/a 1n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...

US Patent US8846689 (2014)


BindingDB Entry DOI: 10.7270/Q2BC3X7Z
More data for this
Ligand-Target Pair