null

SMILES: COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3[C@@H](C)N(C)C(=O)c23)n1

InChI Key: InChIKey=LCLJUGQQFWCBGK-XMCHAPAWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM134158 (US8846689, 160) Show SMILES COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3[C@@H](C)N(C)C(=O)c23)n1 |r| Show InChI InChI=1S/C28H29Cl2FN6O4/c1-14-15-6-5-7-22(24(15)27(39)37(14)3)41-26-18(30)12-32-28(35-26)34-21-11-17(29)16(10-23(21)40-4)25(38)33-20-8-9-36(2)13-19(20)31/h5-7,10-12,14,19-20H,8-9,13H2,1-4H3,(H,33,38)(H,32,34,35)/t14-,19-,20+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...				US Patent US8846689 (2014) BindingDB Entry DOI: 10.7270/Q2BC3X7Z
					More data for this Ligand-Target Pair