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SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cnc(N)nc12

InChI Key: InChIKey=RAMBKWOHJCPQDQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134781   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM134781
PNG
(US8846698, 244)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H21F3N6O2/c1-13(2)33-12-19(18-11-30-23(28)32-22(18)33)21(35)15-8-17(10-29-9-15)31-20(34)7-14-3-5-16(6-4-14)24(25,26)27/h3-6,8-13H,7H2,1-2H3,(H,31,34)(H2,28,30,32)
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Similars
US Patent
n/an/a 4.69n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...

US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair