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SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)c3[nH]nc4ccccc34)c2)c2cncnc12

InChI Key: InChIKey=KCWUQNWBHBVKDO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 135025   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM135025
PNG
(US8846698, 507)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)c3[nH]nc4ccccc34)c2)c2cncnc12
Show InChI InChI=1S/C23H19N7O2/c1-13(2)30-11-18(17-10-25-12-26-22(17)30)21(31)14-7-15(9-24-8-14)27-23(32)20-16-5-3-4-6-19(16)28-29-20/h3-13H,1-2H3,(H,27,32)(H,28,29)
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Similars
US Patent
n/an/a 5.45n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...

US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair