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BDBM135100 US8846698, 526

SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)Nc3cc(nn3-c3cnn(C)c3)C3CC3)c2)c2cncnc12

InChI Key: InChIKey=RVVXKLSQRHADPU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 135100   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135100
PNG
(US8846698, 526)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Nc3cc(nn3-c3cnn(C)c3)C3CC3)c2)c2cncnc12
Show InChI InChI=1S/C26H26N10O2/c1-15(2)35-13-21(20-11-28-14-29-25(20)35)24(37)17-6-18(9-27-8-17)31-26(38)32-23-7-22(16-4-5-16)33-36(23)19-10-30-34(3)12-19/h6-16H,4-5H2,1-3H3,(H2,31,32,38)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.51n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair