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BDBM138393 US8877786, Example 3-7::US8993631, 32-4

SMILES: C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O

InChI Key: InChIKey=WTZARVQRNNDSGI-UPOXFFQJNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 138393   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM138393
PNG
(US8877786, Example 3-7 | US8993631, 32-4)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O |r|
Show InChI InChI=1/C21H20ClN3O5/c1-12(21(28)29)23-17(20(27)24-19-11-18(26)25-30-19)9-13-5-7-14(8-6-13)15-3-2-4-16(22)10-15/h2-8,10-12,17,23H,9H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t12-,17-/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM138393
PNG
(US8877786, Example 3-7 | US8993631, 32-4)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O |r|
Show InChI InChI=1/C21H20ClN3O5/c1-12(21(28)29)23-17(20(27)24-19-11-18(26)25-30-19)9-13-5-7-14(8-6-13)15-3-2-4-16(22)10-15/h2-8,10-12,17,23H,9H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t12-,17-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
The in vitro inhibition of recombinant human neutral endopeptidase (NEP, EC 3.424.11) can be determined as follows:Recombinant human neutral endopept...


US Patent US8877786 (2014)


BindingDB Entry DOI: 10.7270/Q28914KV
More data for this
Ligand-Target Pair