BDBM138393 US8877786, Example 3-7::US8993631, 32-4

SMILES: C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O

InChI Key: InChIKey=WTZARVQRNNDSGI-SJCJKPOMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 138393   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Membrane metallo-endopeptidase-like 1 (Homo sapiens (Human))	BDBM138393 (US8877786, Example 3-7 | US8993631, 32-4) Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O |r| Show InChI InChI=1S/C21H20ClN3O5/c1-12(21(28)29)23-17(20(27)24-19-11-18(26)25-30-19)9-13-5-7-14(8-6-13)15-3-2-4-16(22)10-15/h2-8,10-12,17,23H,9H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t12-,17-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...				US Patent US8993631 (2015) BindingDB Entry DOI: 10.7270/Q20C4THK
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM138393 (US8877786, Example 3-7 | US8993631, 32-4) Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O |r| Show InChI InChI=1S/C21H20ClN3O5/c1-12(21(28)29)23-17(20(27)24-19-11-18(26)25-30-19)9-13-5-7-14(8-6-13)15-3-2-4-16(22)10-15/h2-8,10-12,17,23H,9H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t12-,17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description The in vitro inhibition of recombinant human neutral endopeptidase (NEP, EC 3.424.11) can be determined as follows:Recombinant human neutral endopept...				US Patent US8877786 (2014) BindingDB Entry DOI: 10.7270/Q28914KV
					More data for this Ligand-Target Pair