BDBM139312 US8614223, 90

SMILES: ONC(=O)c1cnc(NC2(CC2)c2ccccc2Cl)nc1

InChI Key: InChIKey=PYBVBLKHLKTINB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 139312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM139312 (US8614223, 90) Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2Cl)nc1 Show InChI InChI=1S/C14H13ClN4O2/c15-11-4-2-1-3-10(11)14(5-6-14)18-13-16-7-9(8-17-13)12(20)19-21/h1-4,7-8,21H,5-6H2,(H,19,20)(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM139312 (US8614223, 90) Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2Cl)nc1 Show InChI InChI=1S/C14H13ClN4O2/c15-11-4-2-1-3-10(11)14(5-6-14)18-13-16-7-9(8-17-13)12(20)19-21/h1-4,7-8,21H,5-6H2,(H,19,20)(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM139312 (US8614223, 90) Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2Cl)nc1 Show InChI InChI=1S/C14H13ClN4O2/c15-11-4-2-1-3-10(11)14(5-6-14)18-13-16-7-9(8-17-13)12(20)19-21/h1-4,7-8,21H,5-6H2,(H,19,20)(H,16,17,18)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM139312 (US8614223, 90) Show SMILES ONC(=O)c1cnc(NC2(CC2)c2ccccc2Cl)nc1 Show InChI InChI=1S/C14H13ClN4O2/c15-11-4-2-1-3-10(11)14(5-6-14)18-13-16-7-9(8-17-13)12(20)19-21/h1-4,7-8,21H,5-6H2,(H,19,20)(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	7.4	25
Acetylon Pharmaceuticals, Inc. US Patent					Assay Description Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...				US Patent US8614223 (2013) BindingDB Entry DOI: 10.7270/Q2B27T00
					More data for this Ligand-Target Pair