BDBM139370 ACP-103::Nuplazid::Pimavanserin::Pimavanserin hydrochloride::Pimavanserin tartrate::bis(1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)-3-(4-(2-methylpropoxy)benzyl)urea) (2R,3R)-2,3-dihydroxybutanedioate
SMILES: CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCN(C)CC2)cc1
InChI Key: InChIKey=RKEWSXXUOLRFBX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem | Article PubMed | 0.5 | -11.8 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
ACADIA Pharmaceuticals Inc. | Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem | Article PubMed | 1.60 | -11.1 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
ACADIA Pharmaceuticals Inc. | Assay Description For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem | Article PubMed | n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals Inc. | Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem | PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology Curated by ChEMBL | Assay Description Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl... | J Med Chem 63: 4171-4182 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization ... | Bioorg Med Chem Lett 28: 2039-2049 (2018) Article DOI: 10.1016/j.bmcl.2018.04.059 BindingDB Entry DOI: 10.7270/Q2CJ8H4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM139370 (ACP-103 | Nuplazid | Pimavanserin | Pimavanserin h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals Inc. | Assay Description R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80... | J Pharmacol Exp Ther 317: 910-8 (2006) Article DOI: 10.1124/jpet.105.097006 BindingDB Entry DOI: 10.7270/Q269728N | |||||||||||
More data for this Ligand-Target Pair |