BDBM139552 US8889870, 12::US9388176, 12::US9820989, 12

SMILES: CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1

InChI Key: InChIKey=LQRFELZFGVSAHD-UHFFFAOYSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 139552   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139552 (US8889870, 12 | US9388176, 12 | US9820989, 12) Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1 Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139552 (US8889870, 12 | US9388176, 12 | US9820989, 12) Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1 Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139552 (US8889870, 12 | US9388176, 12 | US9820989, 12) Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1 Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139552 (US8889870, 12 | US9388176, 12 | US9820989, 12) Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1 Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	67	n/a	n/a	n/a	n/a	7.4	n/a
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139552 (US8889870, 12 | US9388176, 12 | US9820989, 12) Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1 Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair