BDBM139559 US8889870, 19::US9388176, 19::US9820989, 19

SMILES: Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1

InChI Key: InChIKey=IXPCSLBRYVUCTH-UHFFFAOYSA-N

Data: 2 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 139559   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (KDR) (Homo sapiens (Human))	BDBM139559 (US8889870, 19 | US9388176, 19 | US9820989, 19) Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1 Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent									US Patent US9820989 (2017)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta) (Homo sapiens (Human))	BDBM139559 (US8889870, 19 | US9388176, 19 | US9820989, 19) Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1 Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent									US Patent US9820989 (2017)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139559 (US8889870, 19 | US9388176, 19 | US9820989, 19) Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1 Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139559 (US8889870, 19 | US9388176, 19 | US9820989, 19) Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1 Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Allergan, Inc. US Patent					Assay Description Biochemical PDGFR.beta. kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 .mu.g of poly-Glu-Tyr (4:1) in 1...				US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) (Homo sapiens (Human))	BDBM139559 (US8889870, 19 | US9388176, 19 | US9820989, 19) Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1 Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.71E+3	n/a	n/a	n/a	n/a	7.4	n/a
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) (Homo sapiens (Human))	BDBM139559 (US8889870, 19 | US9388176, 19 | US9820989, 19) Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1 Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair