BDBM139602 US8889870, 148::US9388176, 148::US9820989, 148
SMILES: Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
InChI Key: InChIKey=LYMPBMGKFUQEMN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM139602 (US8889870, 148 | US9388176, 148 | US9820989, 148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ALLERGAN, INC. US Patent | Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10... | US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM139602 (US8889870, 148 | US9388176, 148 | US9820989, 148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 273 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ALLERGAN, INC. US Patent | Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in... | US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM139602 (US8889870, 148 | US9388176, 148 | US9820989, 148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 273 | n/a | n/a | n/a | n/a | 7.4 | 30 |
ALLERGAN, INC. US Patent | Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1... | US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM139602 (US8889870, 148 | US9388176, 148 | US9820989, 148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 273 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Allergan, Inc. US Patent | Assay Description Biochemical PDGFR.beta. kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 .mu.g of poly-Glu-Tyr (4:1) in 1... | US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM139602 (US8889870, 148 | US9388176, 148 | US9820989, 148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Allergan, Inc. US Patent | Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m... | US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM139602 (US8889870, 148 | US9388176, 148 | US9820989, 148) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.4 | 30 |
ALLERGAN, INC. US Patent | Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m... | US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ | |||||||||||
More data for this Ligand-Target Pair |