BDBM139613 US8889870, 161::US9388176, 161::US9820989, 161

SMILES: CC(C)c1cccc(NC(=O)c2cncc(c2)N2CCc3nc(N)ncc3C2)c1

InChI Key: InChIKey=YXSQFHKRJRWDHD-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 139613   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139613 (US8889870, 161 | US9388176, 161 | US9820989, 161) Show SMILES CC(C)c1cccc(NC(=O)c2cncc(c2)N2CCc3nc(N)ncc3C2)c1 Show InChI InChI=1S/C22H24N6O/c1-14(2)15-4-3-5-18(8-15)26-21(29)16-9-19(12-24-10-16)28-7-6-20-17(13-28)11-25-22(23)27-20/h3-5,8-12,14H,6-7,13H2,1-2H3,(H,26,29)(H2,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	149	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139613 (US8889870, 161 | US9388176, 161 | US9820989, 161) Show SMILES CC(C)c1cccc(NC(=O)c2cncc(c2)N2CCc3nc(N)ncc3C2)c1 Show InChI InChI=1S/C22H24N6O/c1-14(2)15-4-3-5-18(8-15)26-21(29)16-9-19(12-24-10-16)28-7-6-20-17(13-28)11-25-22(23)27-20/h3-5,8-12,14H,6-7,13H2,1-2H3,(H,26,29)(H2,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	149	n/a	n/a	n/a	n/a	7.4	n/a
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139613 (US8889870, 161 | US9388176, 161 | US9820989, 161) Show SMILES CC(C)c1cccc(NC(=O)c2cncc(c2)N2CCc3nc(N)ncc3C2)c1 Show InChI InChI=1S/C22H24N6O/c1-14(2)15-4-3-5-18(8-15)26-21(29)16-9-19(12-24-10-16)28-7-6-20-17(13-28)11-25-22(23)27-20/h3-5,8-12,14H,6-7,13H2,1-2H3,(H,26,29)(H2,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	149	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair