BDBM139616 US8889870, 164::US9388176, 164::US9820989, 164

SMILES: O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1

InChI Key: InChIKey=DETQEUBCKFGKNU-UHFFFAOYSA-N

Data: 2 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 139616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139616 (US8889870, 164 | US9388176, 164 | US9820989, 164) Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1 Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...				US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139616 (US8889870, 164 | US9388176, 164 | US9820989, 164) Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1 Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...				US Patent US9820989 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T6G
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139616 (US8889870, 164 | US9388176, 164 | US9820989, 164) Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1 Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM139616 (US8889870, 164 | US9388176, 164 | US9820989, 164) Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1 Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Allergan, Inc. US Patent					Assay Description Biochemical PDGFR.beta. kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 .mu.g of poly-Glu-Tyr (4:1) in 1...				US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139616 (US8889870, 164 | US9388176, 164 | US9820989, 164) Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1 Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US8889870 (2014) BindingDB Entry DOI: 10.7270/Q25B0158
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM139616 (US8889870, 164 | US9388176, 164 | US9820989, 164) Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1 Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	30
ALLERGAN, INC. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...				US Patent US9388176 (2016) BindingDB Entry DOI: 10.7270/Q2TQ60DZ
					More data for this Ligand-Target Pair