null
SMILES: N[C@@H](CCN(CCNCCc1ccc(Cl)cc1)C[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O
InChI Key: InChIKey=WWKSYRSOVZNFOY-HMDXBLRFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM139690 (US8895245, 75) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.95E+3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Epizyme, Inc. US Patent | Assay Description Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit... | US Patent US8895245 (2014) BindingDB Entry DOI: 10.7270/Q2WW7GBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM139690 (US8895245, 75) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Epizyme, Inc. US Patent | Assay Description Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit... | US Patent US8895245 (2014) BindingDB Entry DOI: 10.7270/Q2WW7GBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM139690 (US8895245, 75) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.56E+3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Epizyme, Inc. US Patent | Assay Description Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit... | US Patent US8895245 (2014) BindingDB Entry DOI: 10.7270/Q2WW7GBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM139690 (US8895245, 75) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.18E+3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Epizyme, Inc. US Patent | Assay Description Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit... | US Patent US8895245 (2014) BindingDB Entry DOI: 10.7270/Q2WW7GBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM139690 (US8895245, 75) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Epizyme, Inc. US Patent | Assay Description Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit... | US Patent US8895245 (2014) BindingDB Entry DOI: 10.7270/Q2WW7GBK | |||||||||||
More data for this Ligand-Target Pair |