BDBM139724 US8895549, 4::US9675616, 4 N-[8-({(2R)-3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-hydroxypropyl}oxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyridine-3-carboxamide

SMILES: COc1c(OC[C@H](O)CN2C[C@H](C)O[C@H](C)C2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12

InChI Key: InChIKey=MKDJNNDENDJJGM-ZIFCJYIRSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 139724   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110α/p85α (Homo sapiens (Human))	BDBM139724 (US8895549, 4 | US9675616, 4 N-[8-({(2R)-3-[(2R,6S)...) Show SMILES COc1c(OC[C@H](O)CN2C[C@H](C)O[C@H](C)C2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:37,t:21| Show InChI InChI=1S/C26H32N6O5/c1-16-12-31(13-17(2)37-16)14-19(33)15-36-21-7-6-20-22(23(21)35-3)29-26(32-10-9-28-24(20)32)30-25(34)18-5-4-8-27-11-18/h4-8,11,16-17,19,33H,9-10,12-15H2,1-3H3,(H,29,30,34)/t16-,17+,19-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description For the assay 50 mL of a 80-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384-well microtiter plate (G...				US Patent US9675616 (2017) BindingDB Entry DOI: 10.7270/Q2H41PKX
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM139724 (US8895549, 4 | US9675616, 4 N-[8-({(2R)-3-[(2R,6S)...) Show SMILES COc1c(OC[C@H](O)CN2C[C@H](C)O[C@H](C)C2)ccc2C3=NCCN3C(NC(=O)c3cccnc3)=Nc12 |r,c:37,t:21| Show InChI InChI=1S/C26H32N6O5/c1-16-12-31(13-17(2)37-16)14-19(33)15-36-21-7-6-20-22(23(21)35-3)29-26(32-10-9-28-24(20)32)30-25(34)18-5-4-8-27-11-18/h4-8,11,16-17,19,33H,9-10,12-15H2,1-3H3,(H,29,30,34)/t16-,17+,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.85	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description As reagents for the kinase reaction itself and the quantification of the reaction product, the PI3-Kinase HTRF Assay kit from Millipore (#33-017) was...				US Patent US8895549 (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZWF
					More data for this Ligand-Target Pair