BDBM139918 US8895745, 401

SMILES: OCCn1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1

InChI Key: InChIKey=DIGMDWTZHTWCSI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM139918 (US8895745, 401) Show SMILES OCCn1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 Show InChI InChI=1S/C21H19F3N6O2/c22-21(23,24)13-26-20(32)28-17-3-1-2-15(8-17)18-11-25-19-9-14(4-5-30(18)19)16-10-27-29(12-16)6-7-31/h1-5,8-12,31H,6-7,13H2,(H2,26,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.704	n/a	n/a	n/a	n/a	7.5	n/a
Astex Therapeutics Limited US Patent					Assay Description Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...				US Patent US8895745 (2014) BindingDB Entry DOI: 10.7270/Q2833QQC
					More data for this Ligand-Target Pair