null

SMILES: CNC1CCN(CC1)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1Cl

InChI Key: InChIKey=YOHVZMKLLLNSJT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase (Mus musculus (Mouse))	BDBM140086 (US8901315, 165) Show SMILES CNC1CCN(CC1)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1Cl Show InChI InChI=1S/C25H32ClN5OS/c1-16-20-15-23(33-25(20)31(29-16)19-6-4-3-5-7-19)24(32)28-18-8-9-22(21(26)14-18)30-12-10-17(27-2)11-13-30/h8-9,14-15,17,19,27H,3-7,10-13H2,1-2H3,(H,28,32)	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	650	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM140086 (US8901315, 165) Show SMILES CNC1CCN(CC1)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1Cl Show InChI InChI=1S/C25H32ClN5OS/c1-16-20-15-23(33-25(20)31(29-16)19-6-4-3-5-7-19)24(32)28-18-8-9-22(21(26)14-18)30-12-10-17(27-2)11-13-30/h8-9,14-15,17,19,27H,3-7,10-13H2,1-2H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair