null

SMILES: Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCNCC1

InChI Key: InChIKey=KWWIPKBVKLHGCM-WGSAOQKQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase (Mus musculus (Mouse))	BDBM140090 (US8901315, 170) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCNCC1 |r,wU:18.20,wD:21.27,(-7.47,3.9,;-6.7,2.57,;-7.6,1.32,;-6.7,.08,;-7.1,-1.41,;-8.58,-1.81,;-8.98,-3.3,;-7.89,-4.39,;-6.4,-3.99,;-6.01,-2.5,;-5.23,.55,;-3.77,.08,;-2.86,1.32,;-3.77,2.57,;-5.23,2.09,;-1.32,1.32,;-.55,-.01,;-.55,2.66,;.99,2.66,;1.76,3.99,;3.3,3.99,;4.07,2.66,;3.3,1.32,;1.76,1.32,;5.61,2.66,;6.28,4.04,;7.78,4.39,;8.98,3.43,;8.98,1.89,;7.78,.93,;6.28,1.27,)| Show InChI InChI=1S/C24H37N5OS/c1-17-21-16-22(31-24(21)29(27-17)20-6-3-2-4-7-20)23(30)26-18-8-10-19(11-9-18)28-14-5-12-25-13-15-28/h16,18-20,25H,2-15H2,1H3,(H,26,30)/t18-,19-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM140090 (US8901315, 170) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCNCC1 |r,wU:18.20,wD:21.27,(-7.47,3.9,;-6.7,2.57,;-7.6,1.32,;-6.7,.08,;-7.1,-1.41,;-8.58,-1.81,;-8.98,-3.3,;-7.89,-4.39,;-6.4,-3.99,;-6.01,-2.5,;-5.23,.55,;-3.77,.08,;-2.86,1.32,;-3.77,2.57,;-5.23,2.09,;-1.32,1.32,;-.55,-.01,;-.55,2.66,;.99,2.66,;1.76,3.99,;3.3,3.99,;4.07,2.66,;3.3,1.32,;1.76,1.32,;5.61,2.66,;6.28,4.04,;7.78,4.39,;8.98,3.43,;8.98,1.89,;7.78,.93,;6.28,1.27,)| Show InChI InChI=1S/C24H37N5OS/c1-17-21-16-22(31-24(21)29(27-17)20-6-3-2-4-7-20)23(30)26-18-8-10-19(11-9-18)28-14-5-12-25-13-15-28/h16,18-20,25H,2-15H2,1H3,(H,26,30)/t18-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair