null

SMILES: CC(=O)N1CCCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1

InChI Key: InChIKey=NIFVHHHZBHSBQS-MEMLXQNLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140091   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase (Mus musculus (Mouse))	BDBM140091 (US8901315, 171) Show SMILES CC(=O)N1CCCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1 |r,wU:13.17,wD:10.10,(10.32,1.89,;8.98,1.12,;8.98,-.42,;7.65,1.89,;7.65,3.43,;6.44,4.39,;4.94,4.04,;4.27,2.66,;4.94,1.27,;6.44,.93,;2.73,2.66,;1.96,3.99,;.42,3.99,;-.35,2.66,;.42,1.32,;1.96,1.32,;-1.89,2.66,;-2.66,1.32,;-1.89,-.01,;-4.2,1.32,;-5.1,2.57,;-6.57,2.09,;-8.03,2.57,;-8.8,3.9,;-8.94,1.32,;-8.03,.08,;-8.43,-1.41,;-9.92,-1.81,;-10.32,-3.3,;-9.23,-4.39,;-7.74,-3.99,;-7.34,-2.5,;-6.57,.55,;-5.1,.08,)| Show InChI InChI=1S/C26H39N5O2S/c1-18-23-17-24(34-26(23)31(28-18)22-7-4-3-5-8-22)25(33)27-20-9-11-21(12-10-20)30-14-6-13-29(15-16-30)19(2)32/h17,20-22H,3-16H2,1-2H3,(H,27,33)/t20-,21-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM140091 (US8901315, 171) Show SMILES CC(=O)N1CCCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1 |r,wU:13.17,wD:10.10,(10.32,1.89,;8.98,1.12,;8.98,-.42,;7.65,1.89,;7.65,3.43,;6.44,4.39,;4.94,4.04,;4.27,2.66,;4.94,1.27,;6.44,.93,;2.73,2.66,;1.96,3.99,;.42,3.99,;-.35,2.66,;.42,1.32,;1.96,1.32,;-1.89,2.66,;-2.66,1.32,;-1.89,-.01,;-4.2,1.32,;-5.1,2.57,;-6.57,2.09,;-8.03,2.57,;-8.8,3.9,;-8.94,1.32,;-8.03,.08,;-8.43,-1.41,;-9.92,-1.81,;-10.32,-3.3,;-9.23,-4.39,;-7.74,-3.99,;-7.34,-2.5,;-6.57,.55,;-5.1,.08,)| Show InChI InChI=1S/C26H39N5O2S/c1-18-23-17-24(34-26(23)31(28-18)22-7-4-3-5-8-22)25(33)27-20-9-11-21(12-10-20)30-14-6-13-29(15-16-30)19(2)32/h17,20-22H,3-16H2,1-2H3,(H,27,33)/t20-,21-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair