BDBM140096 US8901315, 180

SMILES: CN(C1CCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1)C(C)=O

InChI Key: InChIKey=NQMTWDIEHWQFTO-AQYVVDRMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (PDE4) (Mus musculus (Mouse))	BDBM140096 (US8901315, 180) Show SMILES CN(C1CCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1)C(C)=O |r,wU:11.15,wD:8.8,(9.22,4.19,;8.45,2.85,;6.91,2.85,;6.14,1.52,;4.6,1.52,;3.83,2.85,;4.6,4.19,;6.14,4.19,;2.29,2.85,;1.52,4.19,;-.02,4.19,;-.79,2.85,;-.02,1.52,;1.52,1.52,;-2.33,2.85,;-3.1,1.52,;-2.33,.19,;-4.64,1.52,;-5.55,2.77,;-7.01,2.29,;-8.47,2.77,;-9.24,4.1,;-9.38,1.52,;-8.47,.27,;-8.87,-1.21,;-10.36,-1.61,;-10.76,-3.1,;-9.67,-4.19,;-8.18,-3.79,;-7.78,-2.3,;-7.01,.75,;-5.55,.27,;9.22,1.52,;10.76,1.52,;8.45,.19,)| Show InChI InChI=1S/C27H41N5O2S/c1-18-24-17-25(35-27(24)32(29-18)23-7-5-4-6-8-23)26(34)28-20-9-11-22(12-10-20)31-15-13-21(14-16-31)30(3)19(2)33/h17,20-23H,4-16H2,1-3H3,(H,28,34)/t20-,22-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM140096 (US8901315, 180) Show SMILES CN(C1CCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1)C(C)=O |r,wU:11.15,wD:8.8,(9.22,4.19,;8.45,2.85,;6.91,2.85,;6.14,1.52,;4.6,1.52,;3.83,2.85,;4.6,4.19,;6.14,4.19,;2.29,2.85,;1.52,4.19,;-.02,4.19,;-.79,2.85,;-.02,1.52,;1.52,1.52,;-2.33,2.85,;-3.1,1.52,;-2.33,.19,;-4.64,1.52,;-5.55,2.77,;-7.01,2.29,;-8.47,2.77,;-9.24,4.1,;-9.38,1.52,;-8.47,.27,;-8.87,-1.21,;-10.36,-1.61,;-10.76,-3.1,;-9.67,-4.19,;-8.18,-3.79,;-7.78,-2.3,;-7.01,.75,;-5.55,.27,;9.22,1.52,;10.76,1.52,;8.45,.19,)| Show InChI InChI=1S/C27H41N5O2S/c1-18-24-17-25(35-27(24)32(29-18)23-7-5-4-6-8-23)26(34)28-20-9-11-22(12-10-20)31-15-13-21(14-16-31)30(3)19(2)33/h17,20-23H,4-16H2,1-3H3,(H,28,34)/t20-,22-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair