BDBM140098 US8901315, 184

SMILES: Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCC(N)CC1

InChI Key: InChIKey=BYXDQJDRZRFHOB-WGSAOQKQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (PDE4) (Mus musculus (Mouse))	BDBM140098 (US8901315, 184) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCC(N)CC1 |r,wU:18.20,wD:21.27,(-8.09,4.1,;-7.32,2.77,;-8.23,1.52,;-7.32,.27,;-7.72,-1.21,;-9.21,-1.61,;-9.6,-3.1,;-8.52,-4.19,;-7.03,-3.79,;-6.63,-2.3,;-5.86,.75,;-4.39,.27,;-3.49,1.52,;-4.39,2.77,;-5.86,2.29,;-1.95,1.52,;-1.18,.19,;-1.18,2.85,;.36,2.85,;1.13,4.19,;2.67,4.19,;3.44,2.85,;2.67,1.52,;1.13,1.52,;4.98,2.85,;5.75,1.52,;7.29,1.52,;8.06,2.85,;9.6,2.85,;7.29,4.19,;5.75,4.19,)| Show InChI InChI=1S/C24H37N5OS/c1-16-21-15-22(31-24(21)29(27-16)20-5-3-2-4-6-20)23(30)26-18-7-9-19(10-8-18)28-13-11-17(25)12-14-28/h15,17-20H,2-14,25H2,1H3,(H,26,30)/t18-,19-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM140098 (US8901315, 184) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCC(N)CC1 |r,wU:18.20,wD:21.27,(-8.09,4.1,;-7.32,2.77,;-8.23,1.52,;-7.32,.27,;-7.72,-1.21,;-9.21,-1.61,;-9.6,-3.1,;-8.52,-4.19,;-7.03,-3.79,;-6.63,-2.3,;-5.86,.75,;-4.39,.27,;-3.49,1.52,;-4.39,2.77,;-5.86,2.29,;-1.95,1.52,;-1.18,.19,;-1.18,2.85,;.36,2.85,;1.13,4.19,;2.67,4.19,;3.44,2.85,;2.67,1.52,;1.13,1.52,;4.98,2.85,;5.75,1.52,;7.29,1.52,;8.06,2.85,;9.6,2.85,;7.29,4.19,;5.75,4.19,)| Show InChI InChI=1S/C24H37N5OS/c1-16-21-15-22(31-24(21)29(27-16)20-5-3-2-4-6-20)23(30)26-18-7-9-19(10-8-18)28-13-11-17(25)12-14-28/h15,17-20H,2-14,25H2,1H3,(H,26,30)/t18-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair