BDBM140184 US8901315, 416

SMILES: CN1CCN([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C(=O)C1

InChI Key: InChIKey=PKDPDIGYQHRQKY-IYARVYRRSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (PDE4) (Mus musculus (Mouse))	BDBM140184 (US8901315, 416) Show SMILES CN1CCN([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C(=O)C1 |r,wU:8.11,wD:5.4,(9.6,2.19,;8.06,2.19,;7.29,.85,;5.75,.85,;4.98,2.19,;3.44,2.19,;2.67,3.52,;1.13,3.52,;.36,2.19,;1.13,.85,;2.67,.85,;-1.18,2.19,;-1.95,.85,;-1.18,-.48,;-3.49,.85,;-4.39,2.1,;-5.86,1.62,;-7.32,2.1,;-8.09,3.43,;-8.23,.85,;-7.32,-.39,;-7.72,-1.88,;-9.21,-2.28,;-9.6,-3.77,;-8.52,-4.85,;-7.03,-4.46,;-6.63,-2.97,;-5.86,.08,;-4.39,-.39,;5.75,3.52,;4.98,4.85,;7.29,3.52,)| Show InChI InChI=1S/C24H35N5O2S/c1-16-20-14-21(32-24(20)29(26-16)19-6-4-3-5-7-19)23(31)25-17-8-10-18(11-9-17)28-13-12-27(2)15-22(28)30/h14,17-19H,3-13,15H2,1-2H3,(H,25,31)/t17-,18-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM140184 (US8901315, 416) Show SMILES CN1CCN([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C(=O)C1 |r,wU:8.11,wD:5.4,(9.6,2.19,;8.06,2.19,;7.29,.85,;5.75,.85,;4.98,2.19,;3.44,2.19,;2.67,3.52,;1.13,3.52,;.36,2.19,;1.13,.85,;2.67,.85,;-1.18,2.19,;-1.95,.85,;-1.18,-.48,;-3.49,.85,;-4.39,2.1,;-5.86,1.62,;-7.32,2.1,;-8.09,3.43,;-8.23,.85,;-7.32,-.39,;-7.72,-1.88,;-9.21,-2.28,;-9.6,-3.77,;-8.52,-4.85,;-7.03,-4.46,;-6.63,-2.97,;-5.86,.08,;-4.39,-.39,;5.75,3.52,;4.98,4.85,;7.29,3.52,)| Show InChI InChI=1S/C24H35N5O2S/c1-16-20-14-21(32-24(20)29(26-16)19-6-4-3-5-7-19)23(31)25-17-8-10-18(11-9-17)28-13-12-27(2)15-22(28)30/h14,17-19H,3-13,15H2,1-2H3,(H,25,31)/t17-,18-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair