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BDBM140307 US8912173, 33

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)ccc2c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=OJGZBNSLQQIKDU-HUUFDIDONA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140307
PNG
(US8912173, 33)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)ccc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C25H23N3O2/c1-15-5-6-18-10-17(7-8-22(18)28-15)19-11-23-21(4-3-9-26-23)24(12-19)30-16(2)20-13-25(29)27-14-20/h3-12,16,20H,13-14H2,1-2H3,(H,27,29)/t16-,20-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair