BDBM140308 US8912173, 34
SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2ccccc2n1)[C@H]1CNC(=O)C1
InChI Key: InChIKey=IUKLCVNKYRSKCU-CRAIPNDOSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM140308 (US8912173, 34) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.5 | -80 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc... | US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T | |||||||||||
More data for this Ligand-Target Pair |