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BDBM140315 US8912173, 41

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]cnc2c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=IZRFVLMIBZRWHE-AYSIPDSENA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140315   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140315
PNG
(US8912173, 41)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]cnc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C22H20N4O2/c1-13(16-10-22(27)24-11-16)28-21-9-15(8-19-17(21)3-2-6-23-19)14-4-5-18-20(7-14)26-12-25-18/h2-9,12-13,16H,10-11H2,1H3,(H,24,27)(H,25,26)/t13-,16-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair