BDBM140316 US8912173, 42

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2cnn(C)c2c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=ZXPWMLFILRTSMQ-RDTXWAMCSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140316 (US8912173, 42) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2cnn(C)c2c1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C23H22N4O2/c1-14(18-11-23(28)25-12-18)29-22-10-17(8-20-19(22)4-3-7-24-20)15-5-6-16-13-26-27(2)21(16)9-15/h3-10,13-14,18H,11-12H2,1-2H3,(H,25,28)/t14-,18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair