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SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(cn1)C(F)(F)F)[C@H]1CNC(=O)C1

InChI Key: InChIKey=PXYKBAKIWLJULL-TZMCWYRMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140323   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM140323
PNG
(US8912173, 49)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(cn1)C(F)(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1S/C21H18F3N3O2/c1-12(14-9-20(28)27-10-14)29-19-8-13(7-18-16(19)3-2-6-25-18)17-5-4-15(11-26-17)21(22,23)24/h2-8,11-12,14H,9-10H2,1H3,(H,27,28)/t12-,14-/m1/s1
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Similars
US Patent
n/an/a 0.5n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair