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BDBM140327 US8912173, 53

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2C(=O)NCCc2c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=IXZHTMNQSSSAPE-SHTGXJIWNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140327
PNG
(US8912173, 53)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2C(=O)NCCc2c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H23N3O3/c1-14(18-12-23(28)27-13-18)30-22-11-17(10-21-20(22)3-2-7-25-21)15-4-5-19-16(9-15)6-8-26-24(19)29/h2-5,7,9-11,14,18H,6,8,12-13H2,1H3,(H,26,29)(H,27,28)/t14-,18-/s2
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair