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SMILES: NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1

InChI Key: InChIKey=HFVGRECDVIUAAZ-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140336   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM140336
PNG
(US8912173, 62)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1
Show InChI InChI=1S/C25H21ClN4O2/c26-20-11-15(5-6-19(20)25(28)7-8-25)16-12-21-17(3-1-9-29-21)23(13-16)32-14-22-18(24(27)31)4-2-10-30-22/h1-6,9-13H,7-8,14,28H2,(H2,27,31)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair