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BDBM140361 US8912173, 86

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=MSDFJOGKNPZOCQ-GCMOIQJANA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140361   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140361
PNG
(US8912173, 86)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H24ClN3O2/c1-14(17-12-23(29)28-13-17)30-22-11-16(10-21-18(22)3-2-8-27-21)15-4-5-19(20(25)9-15)24(26)6-7-24/h2-5,8-11,14,17H,6-7,12-13,26H2,1H3,(H,28,29)/t14-,17-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair