BDBM140363 US8912173, 88

SMILES: COc1ccc(nc1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1

InChI Key: InChIKey=UIQJFQAOJKLFFB-UKRRQHHQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140363 (US8912173, 88) Show SMILES COc1ccc(nc1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r| Show InChI InChI=1S/C21H21N3O3/c1-13(15-10-21(25)24-11-15)27-20-9-14(8-19-17(20)4-3-7-22-19)18-6-5-16(26-2)12-23-18/h3-9,12-13,15H,10-11H2,1-2H3,(H,24,25)/t13-,15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair