BDBM140365 US8912173, 90

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(OC2CCC2)nc1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=XRYQZJKKWOKJRI-CRAIPNDOSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140365 (US8912173, 90) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(OC2CCC2)nc1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C24H25N3O3/c1-15(18-12-23(28)26-14-18)29-22-11-17(10-21-20(22)6-3-9-25-21)16-7-8-24(27-13-16)30-19-4-2-5-19/h3,6-11,13,15,18-19H,2,4-5,12,14H2,1H3,(H,26,28)/t15-,18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair