BDBM140381 US8912173, 106

SMILES: Cc1nc2cc(ccc2n1C)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1

InChI Key: InChIKey=FITNTDDQDXTUHS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140381   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140381 (US8912173, 106) Show SMILES Cc1nc2cc(ccc2n1C)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1 Show InChI InChI=1S/C25H21N5O2/c1-15-29-21-11-16(7-8-23(21)30(15)2)17-12-20-18(5-3-9-27-20)24(13-17)32-14-22-19(25(26)31)6-4-10-28-22/h3-13H,14H2,1-2H3,(H2,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair