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BDBM140395 US8912173, 120

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)C(F)F)[C@H]1CNC(=O)C1

InChI Key: InChIKey=KCMATVIEFKVWOM-JTFITGRYNA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140395   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140395
PNG
(US8912173, 120)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)C(F)F)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C21H19F2N3O2/c1-12(15-9-20(27)26-11-15)28-19-8-14(7-18-16(19)3-2-6-24-18)13-4-5-17(21(22)23)25-10-13/h2-8,10,12,15,21H,9,11H2,1H3,(H,26,27)/t12-,15-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair