BDBM140395 US8912173, 120

SMILES: C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)C(F)F)[C@H]1CNC(=O)C1

InChI Key: InChIKey=KCMATVIEFKVWOM-IUODEOHRSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140395 (US8912173, 120) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)C(F)F)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C21H19F2N3O2/c1-12(15-9-20(27)26-11-15)28-19-8-14(7-18-16(19)3-2-6-24-18)13-4-5-17(21(22)23)25-10-13/h2-8,10,12,15,21H,9,11H2,1H3,(H,26,27)/t12-,15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair