BDBM140538 US8912221, 11

SMILES: C[C@@H](NC(=O)C1(COC1)NC(=O)c1cncnc1)c1ncc(cc1F)-c1cc(Cl)cc(Cl)c1OCC(F)F

InChI Key: InChIKey=LLDFSJPKIXSOIR-GFCCVEGCSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140538   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bradykinin B1 receptor (Homo sapiens (Human))	BDBM140538 (US8912221, 11) Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1cncnc1)c1ncc(cc1F)-c1cc(Cl)cc(Cl)c1OCC(F)F |r| Show InChI InChI=1S/C24H20Cl2F3N5O4/c1-12(33-23(36)24(9-37-10-24)34-22(35)14-5-30-11-31-6-14)20-18(27)2-13(7-32-20)16-3-15(25)4-17(26)21(16)38-8-19(28)29/h2-7,11-12,19H,8-10H2,1H3,(H,33,36)(H,34,35)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.60	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...				US Patent US8912221 (2014) BindingDB Entry DOI: 10.7270/Q2668BWC
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