BDBM140545 US8912221, 18

SMILES: COc1cc(on1)C(=O)NC1(COC1)C(=O)N[C@H](C)c1ncc(cc1F)-c1cc(Cl)cc(Cl)c1OCC(F)F

InChI Key: InChIKey=JZNLJBXURXFTNR-LLVKDONJSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140545   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bradykinin B1 receptor (Homo sapiens (Human))	BDBM140545 (US8912221, 18) Show SMILES COc1cc(on1)C(=O)NC1(COC1)C(=O)N[C@H](C)c1ncc(cc1F)-c1cc(Cl)cc(Cl)c1OCC(F)F |r| Show InChI InChI=1S/C24H21Cl2F3N4O6/c1-11(31-23(35)24(9-37-10-24)32-22(34)17-6-19(36-2)33-39-17)20-16(27)3-12(7-30-20)14-4-13(25)5-15(26)21(14)38-8-18(28)29/h3-7,11,18H,8-10H2,1-2H3,(H,31,35)(H,32,34)/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...				US Patent US8912221 (2014) BindingDB Entry DOI: 10.7270/Q2668BWC
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