BDBM140549 US8912221, 22

SMILES: C[C@@H](NC(=O)C1(COC1)NC(=O)C(F)(F)F)c1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1

InChI Key: InChIKey=PNXLQFRHHHRCHN-SNVBAGLBSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140549   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B1 bradykinin receptor (Homo sapiens (Human))	BDBM140549 (US8912221, 22) Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)C(F)(F)F)c1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1 |r| Show InChI InChI=1S/C22H18ClF5N6O3/c1-10(29-19(35)21(8-37-9-21)30-20(36)22(26,27)28)13-4-3-11(5-15(13)24)14-6-12(23)7-16(25)17(14)18-31-33-34(2)32-18/h3-7,10H,8-9H2,1-2H3,(H,29,35)(H,30,36)/t10-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.70	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...				US Patent US8912221 (2014) BindingDB Entry DOI: 10.7270/Q2668BWC
					More data for this Ligand-Target Pair