BDBM140552 US8912221, 25

SMILES: C[C@@H](NC(=O)C1(COC1)NC(=O)c1ccnnc1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1

InChI Key: InChIKey=TWUIXZVQIZSZNL-GFCCVEGCSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140552   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B1 bradykinin receptor (Homo sapiens (Human))	BDBM140552 (US8912221, 25) Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1ccnnc1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1 |r| Show InChI InChI=1S/C25H20ClF2N7O4/c1-12(32-24(37)25(10-38-11-25)34-23(36)14-3-4-30-31-9-14)21-19(28)5-15(8-29-21)17-6-16(26)7-18(27)20(17)22-33-13(2)39-35-22/h3-9,12H,10-11H2,1-2H3,(H,32,37)(H,34,36)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...				US Patent US8912221 (2014) BindingDB Entry DOI: 10.7270/Q2668BWC
					More data for this Ligand-Target Pair