BDBM141033 US10570123, Example 258::US8916576, 258

SMILES: CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1

InChI Key: InChIKey=HTMDBMNLJBQUKZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141033   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141033 (US10570123, Example 258 | US8916576, 258) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1 Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141033 (US10570123, Example 258 | US8916576, 258) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1 Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141033 (US10570123, Example 258 | US8916576, 258) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1 Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	255	n/a	n/a	n/a	n/a	n/a	n/a
SURFACE LOGIX, LLC US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US10570123 (2020) BindingDB Entry DOI: 10.7270/Q2542R1V
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM141033 (US10570123, Example 258 | US8916576, 258) Show SMILES CCCC(=O)Nc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc(OCC3CC3)ccc2n1 Show InChI InChI=1S/C29H28N6O2/c1-2-4-27(36)31-21-6-3-5-19(13-21)28-33-26-12-10-23(37-17-18-7-8-18)15-24(26)29(34-28)32-22-9-11-25-20(14-22)16-30-35-25/h3,5-6,9-16,18H,2,4,7-8,17H2,1H3,(H,30,35)(H,31,36)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Surface Logix, Inc. US Patent					Assay Description ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).				US Patent US8916576 (2014) BindingDB Entry DOI: 10.7270/Q2P55M6K
					More data for this Ligand-Target Pair