null
SMILES: Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1
InChI Key: InChIKey=UOXHLYMLCPPNGX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human)) | BDBM141402 (US10668051, Compound Example 28 | US8921364, 28) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 60.3 | n/a | n/a | n/a | n/a | n/a | n/a |
RHIZEN PHARMACEUTICALS SA US Patent | Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur... | US Patent US10668051 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human)) | BDBM141402 (US10668051, Compound Example 28 | US8921364, 28) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 60.3 | n/a | n/a | n/a | n/a | n/a | 37 |
Rhizen Pharmaceuticals SA US Patent | Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu... | US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N | |||||||||||
More data for this Ligand-Target Pair |