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SMILES: Fc1cccc(F)c1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1

InChI Key: InChIKey=FQBXOFLHBKDTPO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141403   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141403 (US10668051, Compound Example 33 | US8921364, 33) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C22H18F3N3O/c23-15-2-1-3-16(24)21(15)22(29)26-14-8-9-19(17(25)10-14)28-20(13-6-7-13)11-18(27-28)12-4-5-12/h1-3,8-13H,4-7H2,(H,26,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141403 (US10668051, Compound Example 33 | US8921364, 33) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C22H18F3N3O/c23-15-2-1-3-16(24)21(15)22(29)26-14-8-9-19(17(25)10-14)28-20(13-6-7-13)11-18(27-28)12-4-5-12/h1-3,8-13H,4-7H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair