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SMILES: Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(C2CC2)c(Cl)c1C1CC1

InChI Key: InChIKey=RFTNCPFRYIPUHX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141406 (US10668051, Compound Example 37 | US8921364, 37) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(C2CC2)c(Cl)c1C1CC1 Show InChI InChI=1S/C19H17ClFN5OS/c1-9-18(28-25-23-9)19(27)22-12-6-7-14(13(21)8-12)26-17(11-4-5-11)15(20)16(24-26)10-2-3-10/h6-8,10-11H,2-5H2,1H3,(H,22,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020) BindingDB Entry DOI: 10.7270/Q2V40Z7G
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141406 (US10668051, Compound Example 37 | US8921364, 37) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(C2CC2)c(Cl)c1C1CC1 Show InChI InChI=1S/C19H17ClFN5OS/c1-9-18(28-25-23-9)19(27)22-12-6-7-14(13(21)8-12)26-17(11-4-5-11)15(20)16(24-26)10-2-3-10/h6-8,10-11H,2-5H2,1H3,(H,22,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair